C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) C12N 5/071 (2010.01) C12M 1/00 (2006.01) C12M 3/00 (2006.01) C12N 1/38 (2006.01) C12N 5/00 (2006.01) G01N 33/50 (2006.01) A61K 35/12 (2006.01) B81B 1/00 (2006.01)
Patent
CA 2422762
The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions of a main body portion of a single cell, and able, in certain embodiments, to establish long-term gradients of active substances within subcellular regions of a single cell. The present invention provides, in some embodiments, techniques for selectively contacting a portion of the surface of a biological cell with a fluid or fluid component carrying a particular potential for a physiological or biochemical interaction with the cell, and simultaneously contacting a different portion of the surface of the cell with another fluid or fluid component having a different portion of the surface of the cell with another fluid or fluid component having a different potential for the biophysical or biochemical interaction with the cell.
L'invention concerne, dans certains modes de réalisation, des systèmes et des procédés à petite échelle améliorés capables de traiter sélectivement des parties d'une seule cellule, y compris, dans certains modes de réalisation, des parties d'un corps principal d'une seule cellule, et capables, dans certains modes de réalisation, d'établir des gradients à long terme de substances actives dans les zones infracellulaires d'une seule cellule. L'invention concerne, dans certains modes de réalisation, des techniques permettant de mettre sélectivement en contact une partie de la surface d'une cellule biologique avec un fluide ou un composant fluidique présentant un potentiel particulier pour une interaction biophysique ou biochimique avec la cellule, et simultanément à mettre en contact une partie différente de la surface de la cellule avec un autre fluide ou composant fluidique présentant potentiel différent pour l'interaction biophysique ou biochimique avec la cellule.
Ingber Donald E.
Leduc Philip
Naruse Keiji
Ostuni Emanuele
Takayama Shuichi
Cassan Maclean
Children's Medical Center Corporation
President And Fellows Of Harvard College
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