Differentially expressed epitopes and uses thereof

Details Differentially expressed epitopes and uses thereof Differentially expressed epitopes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01H 1/00 (2006.01) A01H 5/00 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/79 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2420276

Provided are among others novel epitopes, methods for finding these epitopes and binding molecules capable of binding to said novel epitopes. In one aspect the invention provides a binding molecule capable of specifically binding to a preferably, post-translationally modified, disease associated molecular marker, associated with diseased cells, whereas said preferably post- translationally modified disease associated molecular marker is not associated with non-diseased cells. In a preferred aspect of the invention, said binding molecule recognizes an epitope present in a subset of CD46 proteins. Said binding molecule is capable of distinguishing between CD46 proteins belonging to the subset and CD46 proteins not belonging to the subset. The binding molecule is preferably an antibody. Medicaments and uses of binding molecules are provided.

L'invention concerne, entre autres, des nouveaux épitopes, des procédés servant à trouver ces épitopes et à lier des molécules capables de se lier à ces nouveaux épitopes. Dans l'un de ses aspects, l'invention concerne une molécule de liaison capable de se lier spécifiquement à un marqueur moléculaire associé à une maladie, lequel est modifié de manière préférablement post-translationnelle, est associé à des cellules malades, mais n'est pas associé à des cellules non malades. Dans un aspect préféré de l'invention, cette molécule de liaison reconnaît un épitope présent dans un sous-ensemble de protéines CD46. Cette molécule de liaison est capable de faire la distinction entre des protéines CD46 appartenant audit sous-ensemble, et des protéines CD46 n'appartenant pas à ce sous-ensemble. De préférence, cette molécule de liaison est un anticorps. L'invention concerne encore des médicaments et des utilisations des molécules de liaison.

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