Differentially expressed genes associated with obesity and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 3/00 (2006.01) A61P 3/06 (2006.01) C07K 14/47 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2463578

The present invention relates to nucleic acid molecules which encode expression products associated with the modulation of obesity, anorexia, weight maintenance, diabetes and/or metabolic energy levels. The nucleic acid molecules and expression products of the present invention are produced by recombinant means or isolated from natural resources. The subject nucleic acid molecules and expression products and their derivatives, homologs, analogs and mimetics are proposed to be useful as therapeutic and diagnostic agents for obesity, anorexia, weight maintenance, diabetes and/or energy imbalance or as targets for the design and/or identification of modulators of their activity and/or function. The subject nucleic acid molecules and expression products are identified using differential display techniques.

L'invention concerne des molécules d'acides nucléiques codant des produits d'expression associés à la modulation de l'obésité, l'anorexie, du maintien du poids, du diabète et/ou des niveaux d'énergie métabolique. Les molécules d'acides nucléiques et les produits d'expression de l'invention sont produits à l'aide de moyens de recombinaison ou isolés dans des ressources naturelles. Les molécules d'acides nucléiques et les produits d'expression ainsi que leurs dérivés, homologues, analogues et mimétiques sont utilisés comme agents thérapeutiques et diagnostiques pour l'obésité, l'anorexie, le maintien du poids, le diabète et/ou le déséquilibre d'énergie ou comme cibles pour la conception et/ou l'identification de modulateurs de leur activité et/ou fonction. Les molécules d'acides nucléiques et les produits d'expression de l'invention sont identifiés à l'aide de techniques d'affichage différentiel.

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