C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) C40B 40/06 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2389751
The present invention is directed to nucleic acid sequences and the polypeptides encoded thereby that are differentially expressed in angiogenesis. Also provided are methods for stimulating or inhibiting angiogenesis in mammals, including humans. Pharmaceutical compositions based on polypeptides, agonists, or antagonists thereto are also provided. Additionally, the invention also provides methods for diagnosing and treating angiogenic disorders including, but not limited to, wound healing and cancer.
L'invention concerne des séquences d'acide nucléique et leurs polypeptides codés, exprimés de manière différentielle dans l'angiogénèse. L'invention concerne également des techniques de stimulation ou d'inhibition de l'angiogénèse chez les mammifères, notamment les humains. Elle concerne en outre des compositions pharmaceutiques à base de polypeptides, d'agonistes, ou d'antagonistes. Elle concerne, enfin, des techniques permettant de diagnostiquer et de traiter des troubles de l'angiogénèse notamment la cicatrisation de blessures et le cancer.
Gerritsen Mary
Mehraban Fuad
Rastelli Luca
Cassan Maclean
Curagen Corporation
Genentech Inc.
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