C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/107 (2006.01) C07K 14/315 (2006.01)
Patent
CA 2618066
The present invention provides a method of synthesizing an intramolecularly bridged polypeptide comprising at least one intramolecular bridge. The present invention further provides a method of synthesizing an intramolecularly bridged polypeptide comprising two intramolecular bridges, wherein the two intramolecular bridges form two overlapping ring, two rings in series, or two embedded rings. The present invention also provides methods for synthesizing lantibiotics, including Nisin A. Additionally, the invention provides intramolecularly bridged polypeptides synthesized by the methods disclosed herein and differentially protected orthogonal lanthionines.
La présente invention concerne un procédé de synthétisation d~un polypeptide à pontage intramoléculaire comprenant au moins un pont intramoléculaire. La présente invention concerne également un procédé de synthétisation d~un polypeptide à pontage intramoléculaire comprenant deux ponts intramoléculaires, où les deux ponts intramoléculaires forment deux anneaux se chevauchant, deux anneaux en série, ou deux anneaux combinés. La présente invention concerne également des procédés de synthétisation d~antibiotiques, englobant la Nisine A. En outre, l~invention concerne des polypeptides à pontage intramoléculaire synthétisés au moyen des procédés divulgués ici, et des lanthionines orthogonales protégées de manière différentielle.
Hillman Jeffrey D.
Orugunty Ravi S.
Smith James Leif
Mbm Intellectual Property Law Llp
Oragenics Inc.
LandOfFree
Differentially protected orthogonal lanthionine technology does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Differentially protected orthogonal lanthionine technology, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Differentially protected orthogonal lanthionine technology will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1718496