C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
150/13, 167/37,
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2007305
A Differentiation Antigen, NDA4, Associated With The Receptor for B Cell Growth Factor Abstract of the Disclosure This invention provides a purified new differentiation antigen, designated NDA4, associated with the growth and proliferation of activated B lymphocytes and characterized by a molecular weight of about 46,000 daltons. The invention also provides an antibody capable of specifically forming a complex with purified NDA4, and a hybridoma which produces a monoclonal antibnody that specifically recognizes the isolated NDA4. The invention also pertains to a method for dectecting B cells or helper T cells, each of which has a B cell growth factor receptor, which comprises contacting a sample which contains B cells or helper T cells with substances capable of forming complexes with the B cell growth factor receptors so as to form cellular complexes between the substances and the B cell growth factor receptors, and detecting such cellular complexes.
King Donald W.
Suciu-Foca Nicole
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University
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