C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/02 (2006.01) C12N 5/077 (2010.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2490261
This invention discloses methods and agents for modulating the differentiation potential and/or proliferation of preadipocytes. More particularly, the present invention discloses methods and agents for modulating a fibroblast growth factor (FGF) signaling pathway, especially the FGF-1 or FGF-2 signaling pathway, for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.
L'invention concerne des méthodes et des agents permettant de moduler le potentiel de différenciation et/ou la prolifération de pré-adipocytes. Plus particulièrement, cette invention a trait à des méthodes et à des agents de modulation d'une voie de signalisation d'un facteur de croissance de fibroblaste (FGF), plus spécifiquement, la voie de signalisation FGF-1 ou FGF-2, dans le traitement ou la prévention de troubles liés à l'adiposité, notamment, mais non seulement, l'obésité, le lipome, la lipomatose, l'émaciation ou la lipodystrophie ou la perte de tissus adipeux lors de traumas ou de troubles atrophiques.
Hutley Louise Joyce
Prins Johannes Bernhard
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Council Of The Queensland Institute Of Medical Research
The University Of Queensland
Verva Pharmaceuticals Pty Ltd
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