C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) C12N 5/077 (2010.01) C12N 5/0793 (2010.01) A61K 35/30 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2399623
The present invention relates to methods of inducing differentiation of mammalian bone marrow stromal cells into neuronal cells by contacting marrow stromal cells with neuronal differentiation-inducing compounds. Neuronal differentiation-inducing compounds of the invention include anti-oxidants such as, but not limited to, beta-mercaptoethanol, dimethylsulfoxide, butylated hydroxyanisole, butylated hydroxytoluene, ascorbic acid, dimethylfumarate, and n-acetylcysteine. Once induced to differentiate into neuronal cells, the cells can be used for cell therapy, gene therapy, or both, for treatment of diseases, disorders, or conditions of the central nervous system.
La présente invention concerne des procédés permettant d'induire une différentiation des cellules stromales de la moelle osseuse chez un mammifère en cellules neuronales par la mise en contact de ces cellules avec des composés induisant la différentiation neuronale. Ceux-ci comprennent des antioxydants tels que, mais pas uniquement, bêta-mercaptoéthanole, diméthylsulfoxyde, hydroxyanisole butylé, hydroxytoluène butylé, acide ascorbique, diméthylfumarate, et n-acétylcystéine. Une fois les cellules introduites en vue de se différencier en cellules neuronales, elles peuvent être utilisées pour la thérapie cellulaire, la thérapie génique, ou les deux, pour le traitement de maladies, de troubles ou d'états pathologiques du système nerveux central.
Black Ira B.
Prockop Darwin J.
Schwartz Emily
Woodbury Dale L.
Gowling Lafleur Henderson Llp
Philadelphia Health And Education Corporation
University Of Medicine & Dentistry Of New Jersey
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