Differentiation of human embryonic stem cells to cardiomyocytes

C - Chemistry – Metallurgy – 12 – N

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C12N 5/077 (2010.01) C12N 5/0735 (2010.01) C12Q 1/00 (2006.01)

Patent

CA 2518508

A method for inducing cardiomyocyte differentiation of a hES cell, the method comprising co-culturing the hES cell with a cell excreting at least one cardiomyocyte differentiation inducing factor or with an extracellular medium therefrom, under conditions that induce differentiation, cells and cell populations so produced, and uses of the cells.

Cette invention concerne une méthode permettant d'induire une différenciation en cardiomyocyte d'une cellule souche embryonnaire humaine, cette méthode consistant à co-cultiver ladite cellule souche avec une cellule excrétant au moins un facteur de différenciation de cardiomyocyte ou avec un support extracellulaire de ce facteur, dans des conditions induisant une différenciation. L'invention concerne également des cellules et des populations de cellules ainsi produites, et leurs utilisations.

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