C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/073 (2010.01) C12N 5/071 (2010.01) C07K 14/475 (2006.01)
Patent
CA 2729734
The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differen-tiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. The present invention also provides meth-ods to generate and purify agents ca-pable of differentiating pluripotent stem cells into cells expressing mark-ers characteristic of the definitive en-doderm lineage.
La présente invention concerne des procédés permettant dinduire la différenciation de cellules souches pluripotentes. La présente invention concerne en particulier des procédés et des compositions permettant dinduire la différenciation des cellules souches pluripotentes en cellules exprimant des marqueurs caractéristiques de la lignée de l'endoderme définitif. L'invention concerne également des procédés permettant de produire et de purifier des agents capables dinduire la différentiation de cellules souches pluripotentes en cellules exprimant des marqueurs caractéristiques de la lignée de l'endoderme définitif.
Chi Ellen
Connor Judith Ann
Davis Janet
Hunter Michael Joseph
Liu Jia Jian
Centocor Ortho Biotech Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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