C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/073 (2010.01) C12N 5/071 (2010.01)
Patent
CA 2729121
The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.
La présente invention concerne des procédés pour différencier des cellules souches pluripotentes. En particulier, la présente invention concerne des procédés et des compositions pour différencier des cellules souches pluripotentes en cellules exprimant des marqueurs caractéristiques du lignage endodermique définitif comprenant la culture des cellules souches pluripotentes dans un milieu comprenant une quantité suffisante de GDF-8 pour causer la différenciation des cellules souches pluripotentes en cellules exprimant des marqueurs caractéristiques du lignage endodermique définitif.
Bonnet Pascal Ghislain Andre
Davis Janet
Liu Jiajian
Parmenter Christine
Centocor Ortho Biotech Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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