Differentiation of primate pluripotent stem cells to...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/0784 (2010.01) C12N 5/0735 (2010.01) C12N 5/078 (2010.01)

Patent

CA 2718438

Methods for differentiation of primate pluripotent stem cells into cells of hematopoietic lineage with a plurality of exogenous cytokines comprising granulocyte-macrophage colony stimulating factor (GMCSF) and bone morphogenic protein 4 (BMP-4) are disclosed.

La présente invention concerne des procédés de différenciation de cellules souches pluripotentes de primate en cellules de lignage hématopoïétique. Linvention propose en outre des cellules de lignage hématopoïétique différenciées à partir de cellules souches pluripotentes de primate, ainsi que des procédés dutilisation de celles-ci et des kits comprenant celles-ci.

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