Differentiation therapy for sarcomas

Details Differentiation therapy for sarcomas Differentiation therapy for sarcomas

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 31/7088 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2762303

Use of muscle-enriched/specific microRNAs for the treatment of sarcomas, as for example rhabdomyosarcomas, synovial sarcoma, alveolar soft part sarcoma, liposarcoma, and osteosarcoma, wherein the microRNAs are able to stop the development of neoplastic cells and to force the neoplastic cells to differentiate into terminally differentiated muscle cells.

La présente invention a pour objet l'utilisation de micro ARN musculaires enrichis / spécifiques pour le traitement des sarcomes, comme par exemple les rhabdomyosarcomes, le sarcome synovial, le sarcome alvéolaire des tissus mous, le liposarcome, et l'ostéosarcome, les micro ARN étant capables d'arrêter le développement des cellules néoplasiques et de forcer les cellules néoplasiques à se différencier en cellules musculaires à terminaisons différenciées.

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