Difficol, intermediate in antibiotic preparation

Details Difficol, intermediate in antibiotic preparation Difficol, intermediate in antibiotic preparation

C - Chemistry, Metallurgy

07

D

195/129, 260/355

C07D 313/00 (2006.01) C07F 9/655 (2006.01) C12P 1/04 (2006.01) C12P 17/08 (2006.01)

Patent

CA 1253099

TITLE OF THE INVENTION DIFFICOL, INTERMEDIATE IN ANTIBIOTIC PREPARATION ABSTRACT OF THE DISCLOSURE The subject disclosure discloses a chemical intermediate in antibiotic synthesis of the structure: Image wherein R is H or OH and the asterisks indicate asymmetric carbon atoms. Compounds of this type may be obtained by fermentation with a strain of B. subtilis under aerobic conditions. Compounds of the - ii - above structure are biologically inactive but are converted by phosphorylation of the hydroxyl group to produce compounds of the structure: Image II wherein R1 is H or OH, which are useful anti- bacterial substances having a broad spectrum of antibacterial activity.

500631

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