Difluorophenyldiacylhydrazide derivatives

Details Difluorophenyldiacylhydrazide derivatives Difluorophenyldiacylhydrazide derivatives

C - Chemistry, Metallurgy

07

C

C07C 243/38 (2006.01) A61K 31/166 (2006.01)

Patent

CA 2744513

The invention relates to novel difluorphenyl diacylhydrazide derivates of formula I, where R1, R2, R3, R4, R5, R6, and R7 have the meanings indicated in Claim 1, said derivates being kinase inhibitors and useable for treating illnesses and diseases such as diabetes, obesity, metabolic syndrome (dyslipidemia), systemic and pulmonary hypertension, cardiac circulatory diseases, and kidney diseases, in general for all types of fibroses, inflammatory processes, tumors, and tumor illnesses.

La présente invention concerne des nouveaux dérivés de difluorophényl-diacylhydrazides de formule I, dans laquelle R1, R2, R3, R4, R5, R6 et R7 ont les significations données à la revendication 1. Il s'agit d'inhibiteurs de kinases qui peuvent être utilisés dans le traitement de maladies et de troubles tels que le diabète, l'obésité, le syndrome métabolique (dyslipidémie), l'hypertonie systémique et pulmonaire, les maladies cardiovasculaires et les maladies rénales, et généralement dans tous les cas de fibroses, de processus inflammatoires, de tumeurs et de maladies tumorales.

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