C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/3, 260/7
C07J 5/00 (2006.01) C07J 1/00 (2006.01) C07J 7/00 (2006.01)
Patent
CA 1058159
Abstract of the Disclosure A novel group of 18,18-difluorosteroids of the general formula (I) Image wherein St, R1 and R2 have the meanings given hereinafter is producted by a chemically novel process characterised in that a corresponding 18-oxo compound is treated with a compound of the formula, F3SX, wherein X denotes a fluorine atom or an amino group derived from secondary amine. The compounds of the in- vention are useful as pharmaceutical intermediates. A number of them are physiologically active and possess hormone-like properties, e.g. those of sexual and/or adrenocortical hor- mones, such as the gonadotropin-blocking, ovulation-blocking, androgenic, oestrogenic, progestagenic, anabolic, antioesero- genic, antindrogcnic, mineralocorticoid, glucocorticoid and antiinflammatery activity, and can be used in lieu of known hormones or agents possessing corresponding hormone-like pro- perties.
232334
Biollaz Michel
Kalvoda Jaroslav
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