Digital topological analysis of trabecular bone mr images...

Details Digital topological analysis of trabecular bone mr images... Digital topological analysis of trabecular bone mr images...

A - Human Necessities

61

B

A61B 5/103 (2006.01) A61B 8/00 (2006.01) A61B 17/56 (2006.01)

Patent

CA 2381693

The invention provides method, system and device for determining trabecular bone structure and strength by digital topological analysis, and offers, for the first time, a demonstration of superior associations between vertebral deformity and a number of architectural indices measured in the distal radius, thus permitting reliable and noninvasive detection and determination of the pathogenesis of osteoporosis. A preferred embodiment provides imaging in three dimension of a region of trabecular bone, after which the 3D image is converted into a skeletonized surface representation. Digital topological analysis is applied to the converted image, and each image voxel is identified and classified as a curve, a surface, or a junction; and then associated with microarchitectural indices of trabecular bone to quantitatively characterize the trabecular bone network. The invention is applicable in vivo, particularly on human subjects, or ex vivo.

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