Digitalis antibodies, process for the preparation thereof...

Details Digitalis antibodies, process for the preparation thereof... Digitalis antibodies, process for the preparation thereof...

A - Human Necessities

61

K

167/139

A61K 39/395 (2006.01) C07K 16/16 (2006.01) G01N 33/94 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1242393

ABSTRACT A process for the preparation of digitalis antibodies in which appropriate mammals are immunised with a digoxin bound to protein, the animal serum is obtained, the immune globulin-containing protein fraction is separated in known manner, the immuno- logically-active globulins are adsorbed on an immuno- logically-active column and separated from the other proteins, the antibodies are eluted from the column and the Fab fractions are split with papain and purified, wherein, as immunologically-active adsorbent, there is used an inorganic matrix of large surface area to which digitoxin aldehyde is bound via a spacer which cannot be split with papain and the splitting off of the Fab fraction from the antibodies is carried out on the matrix; digitalis antibodies obtained by this process can be used for the theraphy of digitalis intoxications and for preparing immuno- logical reagents for the determination of digitalis glycosides.

466633

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