Diglycerid and sterol based organometallic complexes and...

C - Chemistry – Metallurgy – 07 – J

Patent

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Details

C07J 51/00 (2006.01) A61K 31/575 (2006.01)

Patent

CA 2295867

The invention concerns an organometallic complex obtainable by reacting: a metal cation (M) having an oxidation number of at least 2 capable of being used in the living metabolism; sitosterol, sitostanol or a mixture of sitosterol and sitostanol; diglycerid of formula (I), in which: R1 is an oleic acid radical (C18:1); R2 is a fatty acid radical containing 2 to 18 carbon atoms, linear or branched, saturated or unsaturate. The invention also concerns in particular complexes in which R2 is an oleolyl or acetyl grouping. It also concerns pharmaceutical compositions and dietetic products containing this complex, particularly those in which the metal is vanadium, and their use in the treatment and/or the prevention of hypercholesterolemy and hypertriglyceridemy, of insulin-dependent or non insulin-dependent diabetes, of insulin-resistance and associated pathologies, in particular cardiovascular-vascular.

L'invention concerne un complexe organo-métallique susceptible d'être obtenu par réaction: d'un cation d'un métal (M) au degré d'oxydation au moins égal à 2 utilisable comme biocatalyseur dans le métabolisme vivant; du sitostérol, du sitostanol ou d'un mélange de sitostérol et de sitostanol; du diglycéride répondant à la formule (I) dans laquelle: R1 est un reste acyle d'acide oléique (C18:1) R2 est un reste acyle d'acide gras comprenant entre 2 et 18 atomes de carbone, linéaire ou ramifié, saturé ou insaturé. Elle concerne tout particulièrement les complexes dans lesquels R2 est un groupement oléoyle ou acétyle. Elle concerne aussi des compositions pharmaceutiques et des produits diététiques contenant ce complexe, particulièrement ceux où le métal est le vanadium, et leur utilisation dans le traitemnet et/ou la prévention de l'hypercholestérolémie et/ou de l'hypertriglycéridémie, du diabète insulino- dépendant ou non insulino-dépendant, de l'insulino-résistance et des pathologies associées, en particulier cardio-vasculaires.

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