C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/207 (2006.01) A61K 31/70 (2006.01) C07H 15/04 (2006.01) C07H 15/18 (2006.01) C07H 15/26 (2006.01) C07H 17/00 (2006.01) C07H 17/02 (2006.01) C07H 23/00 (2006.01)
Patent
CA 2224346
Compounds of formula (I) in which X is the residue of a non-glycosidic aliphatic 1,2-diol; R1 is an S-configurated methyl substituted with one carboxyl residue and one other substituent; and R2 is hydrogen, C1-C12alkyl or C6aryl; as mimetics of sialyl-Lewis X and sialyl-Lewis A.
Cette invention concerne des composés représentés par la formule (I), dans laquelle X est le résidu d'un 1,2-diol aliphatique non glycosidique, R¿1? est un méthyle à structure en S substitué par un résidu de carboxyle et par un autre substituant, et R¿2? est hydrogène, C¿1?-C¿12? alkyle ou C¿6? aryle. Ces composés sont utilisés comme agents mimétiques de sialyl-Lewis X et de sialyl-Lewis A.
Kirby Eades Gale Baker
Novartis Ag
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