Digoxin assay

Details Digoxin assay Digoxin assay

G - Physics

01

N

150/14, 150/3, 1

G01N 33/94 (2006.01) G01N 33/533 (2006.01)

Patent

CA 1268705

RAN 4090/165 Abstract The present invention relates to an assay for measuring total serum diqoxin using a combination of centrifugal ultrafiltration and dissociation agents used to dissociate the digoxin bound to the serum proteins. A number of compounds have been found to be effective either alone or in combination in dissociating protein-bound digoxin from the serum proteins. Examples of such effective dissociation agents include quindine, Vitamin E (.alpha.-tocophecol), lower alkanols, and C3-C26 fatty acids, most preferably long chain saturated and unsaturated fatty acids.

506966

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