C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/36 (2006.01) A61K 31/41 (2006.01) A61K 31/426 (2006.01) A61K 31/428 (2006.01) A61K 31/433 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61P 9/00 (2006.01) A61P 19/02 (2006.01) A61P 35/04 (2006.01) C07C 311/28 (2006.01) C07C 311/29 (2006.01) C07C 317/48 (2006.01) C07D 213/65 (2006.01) C07D 213/70 (2006.01) C07D 233/84 (2006.01) C07D 235/28 (2006.01) C07D 239/38 (2006.01) C07D 239/95 (2006.01) C07D 249/10 (2006.01) C07D 249/12 (2006.01) C07D 257/04 (2006.01) C07D 263/5
Patent
CA 2366954
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to formula (I): where J, M, Q, T, W, X, Z, R1, R2, R3, R4, R4', R5, R6, R6', R7, m, and n have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of the formula above, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also disclosed are pharmaceutical compositions comprising these compounds, and methods of treating or preventing metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
La présente invention concerne des composés inhibiteurs de métalloprotéases convenant au traitement d'états caractérisés par une activité excessive de ces enzymes. Plus particulièrement, ces composés présentent une structure conforme à la formule générale (I). Dans cette formule générale (I), les J, M, Q, T, W, X, Z, R?1¿, R?2¿, R?3¿, R?4¿, R?4'¿, R?5¿, R?6¿, R?6'¿, R?7¿, m, et n ont la signification qu'en donnent les spécifications. L'invention concerne également des isomères optiques, des diastéréomères, des énantiomères de cette formule, ainsi que certains de leurs sels, amides biohydrolysables, esters et imides pharmacuetiquement admis. L'invention concerne aussi, d'une part des compositions pharmaceutiques comprenant ces composés, et d'autre part des procédures d'utilisation de ces composés et de ces compositions pharmaceutiques permettant de soigner ou de prévenir des maladies impliquant des métalloprotéases.
Almstead Neil Gregory
Cheng Menyan
De Biswanath
Natchus Michael George
Pikul Stanislaw
Ledgley Law
The Procter & Gamble Company
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