C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4245 (2006.01) A61P 17/06 (2006.01) A61P 17/10 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2711887
The present invention relates to certain (1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- pyrrolo[1,2-a]indol-1-yl carboxylic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, sepsis, myocardial infarction, ischemic stroke, acne, microbial infections or diseases and viral infections or diseases.
La présente invention concerne certains dérivés de l'acide carboxylique (1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yle de Formule (Ia) qui présentent des propriétés pharmacologiques utiles, par exemple, à titre d'agonistes du récepteur S1P1, et les sels pharmaceutiquement acceptables de ceux-ci. La présente invention concerne également des compositions pharmaceutiques contenant les composés selon l'invention, et des procédés d'utilisation des composés et des compositions selon l'invention pour traiter des troubles associés au S1P1, par exemple, le psoriasis, la polyarthrite rhumatoïde, la maladie de Crohn, le rejet de greffe, la sclérose en plaques, le lupus érythémateux disséminé, la rectocolite hémorragique, le diabète du type I, la septicémie, l'infarctus du myocarde, l'attaque ischémique, l'acné, les infections ou les maladies microbiennes et les infections ou les maladies virales.
Buzard Daniel J.
Jones Robert M.
Kawasaki Andrew M.
Lopez Luis A.
Moody Jeanne V.
Arena Pharmaceuticals Inc.
Smart & Biggar
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