Dihydro-2,3-benzodiazepine derivatives

Details Dihydro-2,3-benzodiazepine derivatives Dihydro-2,3-benzodiazepine derivatives

C - Chemistry, Metallurgy

07

D

C07D 491/056 (2006.01) A61K 31/55 (2006.01) C07D 317/58 (2006.01) C07D 491/04 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2198751

Compounds having general formula (I) wherein R is hydrogen or C1-C10 alkyl; X is an aromatic moiety selected from phenyl, thienyl, furyl, pyridyl, imidazolyl, benzimidazolyl, benzothiazolyl and phthalazinyl which is unsubstituted or substituted with one or more moieties chosen from the group consisting of halogen, hydroxy, cyano, nitro, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C4 alkoxy, carboxy, C1-C6 alkoxycarbonyl, acetyl, formyl, carboxymethyl, hydroxymethyl, amino, aminomethyl, methylenedioxy and trifluoromethyl; and "Aryl" represents p-nitrophenyl, p-aminophenyl or p-(protected amino) phenyl; or a pharmaceutically acceptable salt thereof, are useful as anticonvulsants.

Composés de formule générale (I) dans laquelle R est hydrogène ou alkyle C1-C10; X est une fraction aromatique sélectionnée parmi phényle, thiényle, furyle, pyridyle, imidazolyle, benzimidazolyle, benzothiazolyle et phtalazinyle qui est non substitué ou substitué avec une ou plusieurs fractions choisies dans le groupe composé d'halogène, hydroxy, cyano, nitro, alkyle C1-C6, cycloalkyle C3-C6, alcoxy C1-C4, carboxy, alcoxycarbonyle C1-C6, acétyle, formyle, carboxyméthyle, hydroxyméthyle, amino, aminométhyle, méthylènedioxy et trifluorométhyle; et "aryle" représente p-nitrophényle, p-aminophényle ou p-(amino protégé)phényle. Ces composés, ou un de leurs sels acceptable en pharmacologie, sont utiles comme agents anticonvulsifs.

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