C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/54 (2006.01) A61K 31/4164 (2006.01) A61P 43/00 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2406032
The present invention provides dihydro-2H-napthalene-1-ones of formula (V), and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis. Specifically, the present invention relates to compounds that inhibit the farnesyl transferase enzyme.
La présente invention concerne des dihydro-2H-naphtalène-1-ones et des sels, des esters, des amides et des promédicaments pharmaceutiquement acceptables desdits composés, lesquels sont utiles pour traiter et prévenir une prolifération incontrôlée ou anormale de tissus, telle que le cancer, l'athérosclérose, la resténose et le psoriasis. Plus particulièrement, la présente invention se rapporte à des composés inhibant l'enzyme farnésyltransférase.
Leonard Daniele Marie
Repine Joseph Thomas
Rewcastle Gordon William
Sim & Mcburney
Warner-Lambert Company
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