C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 335/12 (2006.01) A61K 31/382 (2006.01) C07D 335/10 (2006.01)
Patent
CA 2475093
The invention relates to dihydro-thia-phenanthrene-carbonyl-guanidines of formula (I); wherein R1 - R9 have the meanings as cited in the description, suitable as anti-arrhythmic medicaments with cardioprotective components for infarct prophylaxis and infarct treatment as well as for the treatment of angina pectoris. Said compounds inhibit as well as prevent the pathophysiological processes resulting from ischemically induced injuries, especially triggering ischemically induced cardiac arrhythmia.
Dihydro-thia-phénanthrène-carbonyl-guanidines de formule (I) dans laquelle R?1¿ à R?9 ¿possèdent la signification figurant dans les revendications, qui sont adaptées en tant que médicaments anti-arythmiques à composante cardioprotectrice pour la prophylaxie et le traitement des infarctus, ainsi que pour le traitement de l'angine de poitrine. Lesdites substances inhibent également de manière préventive les processus pathophysiologiques lors de l'apparition de lésions induites par l'ischémie, en particulier lors du déclenchement d'arythmies cardiaques induites par l'ischémie.
Below Peter
Kleemann Heinz-Werner
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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