Dihydrobenzo¬b|thiophenes and pharmaceutical compositions...

Details Dihydrobenzo¬b|thiophenes and pharmaceutical compositions... Dihydrobenzo¬b|thiophenes and pharmaceutical compositions...

C - Chemistry, Metallurgy

07

D

167/233, 260/305

C07D 409/06 (2006.01) C07D 409/14 (2006.01) C07D 495/10 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1287634

ABSTRACT 2-Alkyl-, 2-alkenyl- and 2-alkynyl-2,3-dihydro-2- (1H-azolyl(C1-C2)alkyl)benzo[b]thiophenes especially 2-alkyl-, 2-alkenyl- and 2-alkynyl-2,3-dihydro-3-hydroxy-2-(1H-1- imidazolylmethyl)-4-, 5-, 6- and 7-halobenzo-[b]thiophenes and related derivatives having antifungal activity are disclosed. Pharmaceutical compositions comprising compounds of the invention and their use in treating fungal infections in susceptible hosts such as humans are also disclosed. These compounds have the following formula Image wherein X is halogen or an organic radical such as (lower)alkyl, Y is substituted or unsubstituted imidazolyl or 1,2,4-triazolyl or phenyl(lower)alkyl, R, and R2 are hydrogen or an organic radical such as (lower)alkyl, R3 is an organic radical such as an alkynyl, n is 1 or 2, m is 1, 2, 3 or 4.

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