C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/78 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) C07D 307/79 (2006.01) C07D 307/94 (2006.01) C07D 333/52 (2006.01) C07D 333/54 (2006.01) C07D 333/78 (2006.01)
Patent
CA 2199128
A compound having the structure (A), wherein (a) W is -C(X')-NRR' or -NR- C(X')R'; (b) X and X' are independently O or S; (c) each Y is independently hydrogen or straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms, or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms; (d) Z is unsubstituted branched or cyclic alkyl, or unsubstituted or alkanyl-substituted phenyl or benzyl, Z having from 3 to about 10 atoms other than hydrogen; (e) R is selected from hydrogen, straight or branched alkyl having from 1 to about 6 carbon atoms, and cyclic alkyl having from 3 to about 6 carbon atoms; and (f) R' is selected from hydrogen, hydroxy, straight or branched alkyl or alkoxy having from 1 to about 6 carbon atoms, and cyclic alkyl having from 3 to about 7 carbon atoms; pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
L'invention concerne un composé ayant la structure (A), dans laquelle: (a) W représente -C(X')-NRR' ou -NR-C(X')R'; (b) X et X' représentent indépendamment O ou S; (c) chaque Y représente indépendamment hydrogène ou alcanyle droit, ramifié ou cyclique présentant 1 à environ 3 atomes de carbone, ou les deux Y sont liés pour former un cycle alcanyle présentant 3 à environ 7 atomes de carbone; (d) Z représente un alkyle non substitué ramifié ou cyclique, ou benzyle ou phényle non substitué ou à substitution alcanyle, Z présentant 3 à environ 10 atomes autres que l'hydrogène; (e) R est choisi entre hydrogène, alkyle droit ou ramifié comportant 1 à environ 6 atomes de carbone et alkyle cyclique comportant 3 à environ 6 atomes de carbone; et (f) R' est choisi parmi hydrogène, hydroxy, alkyle droit ou ramifié ou alcoxy présentant 1 à environ 6 atomes de carbone, et alkyle cyclique présentant 3 à environ 7 atomes de carbone; et des compositions pharmaceutiques comprenant lesdits composés ainsi que des procédés de traitement d'inflammations ou de douleurs à l'aide de ces derniers.
Janusz John Michael
Scherz Michael Wiard
Kirby Eades Gale Baker
The Procter & Gamble Company
Vanderbilt University
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