Dihydrobenzofuran and related compounds useful as...

C - Chemistry – Metallurgy – 07 – D

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C07D 405/06 (2006.01) A61K 31/33 (2006.01) A61K 31/38 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) C07D 307/79 (2006.01) C07D 333/54 (2006.01) C07D 407/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2244199

A compound having structure (A) wherein (a) n is from about 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO2; (c) Y is independently hydrogen or straight, branched or cyclic alkyl or aralkyl having from 1 to about 3 carbon atoms; or the Y's are bonded together to form an alkanyl ring having from 3 to about 7 atoms; (d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; (e) R1 and R2 are each independently hydrogen or straight, branched or cyclic alkyl, unsubstituted or substituted, carboxyl, carboxamido, alkoxycarbonyl or alkylcarbonyl; and (f) Het is a heteroaryl group consisting one or more rings containing from about 5 to about 8 atoms in the rings and wherein at least one ring has at least one heteroatom selected from O, N, or S. Pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

L'invention concerne un composé ayant la structure (A) dans laquelle (a) n vaut d'environ de 1 à environ 3; (b) X est sélectionné dans le groupe constitué par O, S, SO ou SO¿2?; (c) Y représente indépendamment hydrogène ou alkyle ou aralkyle droit, ramifié ou cyclique possédant de 1 à environ 3 atomes de carbone; ou bien les Y sont reliés afin de former un noyau alcanyle possédant de 3 à environ 7 atomes; (d) Z représente hydrogène ou alkyle droit, ramifié ou cyclique possédant de 3 à environ 10 atomes autres que l'hydrogène; (e) R¿1? et R¿2? représentent chacun indépendamment, hydrogène ou alkyle droit, ramifié ou cyclique, non substitué ou substitué, carboxyle, carboxamido, alcoxycarbonyle ou alkylcarbonyle; et (f) Het représente un groupe hétéroaryle comprenant un ou plusieurs noyaux contenant d'environ 5 à environ 8 atomes, au moins un noyau possédant au moins un hétéroatome sélectionné à partir de O, N ou S. L'invention concerne également des compositions pharmaceutiques comprenant ces composés ainsi que des procédés de traitement de l'inflammation ou de la douleur au moyen de ces composés.

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