C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/79 (2006.01) A61K 31/335 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/415 (2006.01) A61K 31/505 (2006.01) C07D 307/94 (2006.01) C07D 311/58 (2006.01) C07D 313/08 (2006.01) C07D 333/54 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)
Patent
CA 2244402
A compound having structure (I) wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO2; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms; (d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; (e) R1 is hydrogen or straight, branched or cyclic alkyl, aryl or C(=NH)-NHR4; and (f) R2, R3 and R4 are independently hydrogen, straight, branched or cyclic alkyl having from one to 10 carbon atoms or aryl, R2 or R3 may be bonded together to form a ring having 5 or 6 atoms. Pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
L'invention concerne un composé ayant la structure (I) dans laquelle (a) n vaut de 1 à environ 3; (b) X est sélectionné dans le groupe constitué par O, S, SO ou SO¿2?; (c) Y représente indépendamment hydrogène ou alkyle droit, ramifié ou cyclique possédant de 1 à environ 4 atomes de carbone, ou bien les Y sont reliés afin de former un noyau alcanyle possédant d'environ 3 à environ 7 atomes; (d) Z représente hydrogène ou alkyle droit, ramifié ou cyclique possédant de 3 à environ 10 atomes autres que l'hydrogène; (e) R¿1? représente hydrogène ou alkyle droit, ramifié ou cyclique, aryle ou C(=NH)-NHR¿4?; et (f) R¿2?, R¿3? et R¿4? représentent indépendamment, hydrogène, alkyle droit, ramifié ou cyclique possédant de 1 à environ 10 atomes de carbone, ou aryle; R¿2?, R¿3? peuvent être liés afin de former un noyau possédant 5 ou 6 atomes. L'invention concerne des compositions pharmaceutiques comprenant ces composés et également des procédés de traitement de l'inflammation ou de la douleur au moyen de ces composés.
Janusz John Michael
Ridgeway James Madison II
Kirby Eades Gale Baker
The Procter & Gamble Company
Vanderbilt University
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