Dihydrobenzofuranyl alkanamine derivatives as 5ht2c agonists

Details Dihydrobenzofuranyl alkanamine derivatives as 5ht2c agonists Dihydrobenzofuranyl alkanamine derivatives as 5ht2c agonists

C - Chemistry, Metallurgy

07

D

C07D 307/81 (2006.01) A61K 31/343 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2605932

Compounds of formula (2) or pharmaceutically acceptable salts thereof are provided: wherein each of Rla, R2a, R3a, Ar, y, and m are as defined herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, are used to treat a variety of central nervous system disorders such as schizophrenia.

La présente invention concerne des composés de formule (2) ou des sels pharmaceutiquement acceptables en dérivant : où chaque Rla, R2a, R3a, Ar, y, et m sont tels que défini ici, qui sont des agonistes ou des agonistes partiaux du sous-type 2C des récepteurs de sérotonine du cerveau. Les composés et compositions contenant les composés, s~utilisent pour traiter tout un ensemble de désordres du système nerveux central tel que la schizophrénie.

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