Dihydrobenzofuranyl derivatives and methods of their use

Details Dihydrobenzofuranyl derivatives and methods of their use Dihydrobenzofuranyl derivatives and methods of their use

C - Chemistry, Metallurgy

07

D

C07D 307/83 (2006.01) A61K 31/343 (2006.01) A61P 25/00 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2672464

The present invention is directed to dihydrobenzofuranyl derivatives of formula (I): or a pharmaceutically acceptable salt thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorder, cognitive disorder, diabetic neuropathy, pain, and Other diseases or disorders.

La présente invention concerne des dérivés dihydrobenzofuranyles de formule (I), ou un sel pharmaceutiquement acceptable de ceux-ci, qui sont des inhibiteurs de recaptage des monoamines, des compositions contenant ces dérivés, et leurs procédés d'utilisation pour la prévention et le traitement de conditions comprenant, entre autres, les symptômes vasomoteurs, de dysfonctionnement sexuel, les troubles gastro-intestinaux, le trouble génito-urinaire, les troubles dépressifs, le trouble du comportement endogène, le trouble cognitif, la neuropathie diabétique, et d'autres maladies ou troubles.

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