Dihydrobenzopyrans, dihydrobenzothiopyrans, and...

C - Chemistry – Metallurgy – 07 – D

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C07D 335/06 (2006.01) A61K 31/353 (2006.01) A61P 29/00 (2006.01) C07D 215/54 (2006.01) C07D 311/58 (2006.01)

Patent

CA 2395795

A class of dihydrobenzopyrans, dihydrobenzothiopyrans, tetrahydroquinolines, tetrahydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula (I) wherein X, A1, A2, A3, A4, R, R'', R1 and R2 are as described in the specification.

L'invention concerne une catégorie de dihydrobenzopyrannes, dihydrobenzothiopyrannes, tétrahydroquinolines, tétrahydronaphthalènes, et leurs analogues, destinés à être utilisés dans le traitement des troubles induits par la cyclooxygénase-2. Les composés présentant un intérêt particulier sont représentés par la formule (I), où X, A?1¿, A?2¿, A?3¿, A?4¿, R, R'', R?1¿ et R?2¿ sont tels que définis dans le descriptif.

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