Dihydroindolone derivatives

Details Dihydroindolone derivatives Dihydroindolone derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/404 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2725001

Disclosed are dihydroindolone compounds which can modulate the activity of protein tyrosine kinases, a method for preparing the same, and pharmaceutical compositions comprising the same. Also disclosed are use of such compounds and pharmaceutical compositions thereof in the treatment and/or prophylaxis of protein tyrosine kinase associated diseases in an organism, particularly in the treatment and/or prophylaxis of tumors and fibroblast proliferation associated diseases.

L'invention porte sur des composés de dihydroindolinone qui peuvent moduler l'activité de protéines tyrosine kinases, sur leur procédé de fabrication, sur des compositions comprenant les composés et sur les utilisations des composés et compositions décrits ici dans le traitement ou la prévention de maladies liées aux protéines tyrosine kinases dans l'organisme, en particulier d'un cancer et des maladies liées à la prolifération de fibroblastes.

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