Dihydroisoquinoline derivatives

Details Dihydroisoquinoline derivatives Dihydroisoquinoline derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/277

C07D 217/22 (2006.01) C07D 217/24 (2006.01) C07D 221/16 (2006.01) C07D 413/04 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01)

Patent

CA 1246069

- 1 - Abstract A compound of formula (I) or a pharmaceutically acceptable salt thereof: Image (I) wherein: R1 and R2 are independently hydrogen, C1-6 alkyl or together are a group X which is C3-6 polymethylene optionally interrupted by O, S or NR6 wherein R6 is hydrogen or Cl-6 alkyl; R3 is phenyl, optionally substituted by ona or more substituents selected from halogen, CF3, nitro, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C2-7 alkanoyl, carboxyl, C1-6 alkoxycarbonyl, cyano, CONR7R8 wherein R7 and R8 are selected from hydrogen or C1-6 alkyl or together are a group X;NR9 R10 wherein R9 and R10 are selected from hydrogen, C1-6 alkyl, C2-7 alkanoyl or C1-6 alkylsulphonyl or together are a group X; SO2NR11R12 wherein R11 and R12 are selected from hydrogen or C1-6 alkyl or together are a group X or S(O)mR13 wherein m is 1 or 2 and R13 is C1-6 alkyl, - 2 - R4 and R5 are independently selected from hydrogen, C1-6 alkyl, cyano, amino, aminocarbonyl or aminocarbamoyl optionally substituted by one or two C1-6 alkyl groups or together are a group X, halogen, CF3, nitro, C1-6 alkoxy,C1-6 alkylthio, C2-7 alkanoyloxy, C1-6 alkoxy or hydroxy, or together are methylenedioxy or C3-5 polymethylene, having anti-inflammatory and/or anti-rheumatic activity, a process for their preparation and their use as pharmaceuticals.

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