A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/525 (2006.01) A61K 31/5377 (2006.01) A61P 1/00 (2006.01) A61P 3/10 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 31/10 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 35/04 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2575787
The present invention relates to the use of a compound of general Formula (1), for the treatment of diseases characterized by abnormal cell proliferation in a human or non-human mammalian body by inhibition of polo like kinases as mitotic regulators like cancer selected from the group consisting of carcinomas, sarcomas, melanomas, myeloma, hematologic neoplasias, lymphomas, childhood cancers and leukemia, autoimmune disorders selected from the group consisting of amyloidosis, systemic lupus erythematosus, rheumatoid arthritis, Crohn~s disease, multiphe sclerosis, systemic sclerosis (scleroderma), mixed connective tissue disease, Sjögren~s syndrome, ankylosing spondylitis, autoimmune vasculitis, Behcet~s syndrome, psoriasis, autoimmune arthritis, sarcoidosis, diabetes mellitus and fungous diseases.
La présente invention a trait à l'utilisation d'un composé de formule générale (1), éventuellement sous la forme de ses tautomères, racémates, énantiomères, diastéréoisomères et des mélanges de ceux-ci et éventuellement sous la forme de sels d'addition à l'acide, de solvates, hydrates, polymorphes, dérivés physiologiquement fonctionnels ou prodrogues de ceux-ci pharmacologiquement acceptables, pour la préparation d'une composition pharmaceutique pour le traitement de maladies caractérisées par une prolifération cellulaire anormale dans un corps mammalien humain ou non humain par l'inhibition des kinases de type polo comme régulateurs mitotiques.
Munzert Gerd
Steegmaier Martin
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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