Dihydropyrazine derivatives as npy antagonists

Details Dihydropyrazine derivatives as npy antagonists Dihydropyrazine derivatives as npy antagonists

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/496 (2006.01) C07D 241/06 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2377698

The present invention provides a series of non-peptidergic antagonists of NPY comprising piperidine and piperazine derivatives of 4-phenyl-1, 4- dihydropyrazines of Formula (I) wherein R, R1, R1 X, Y and Z are defined herein. As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

La présente invention se rapporte à une série d'antagonistes non peptidergiques des neuropeptides Y (NPY) comportant des dérivés pipéridine et pipérazine de 4-phényl-1,4-dihydropyrazines représentés par la formule (I) dans laquelle R, R?1¿, X, Y et Z sont définis dans le descriptif associé. Ces composés sont utilisés en tant qu'antagonistes de comportements alimentaires induits par les NPY du fait qu'ils s'avèrent efficaces en tant qu'agents anorexigènes favorisant une perte de poids et permettant de traiter des troubles alimentaires.

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