C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/06 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C07D 231/06 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2478068
The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
L'invention concerne des composés dihydropyrazole utiles dans le traitement des maladies prolifératives, de troubles associés à l'activité de kinésine KSP et afin d'inhiber la kinésine KSP. L'invention concerne aussi des compositions comprenant ces composés, ainsi que des méthodes d'utilisation de ces composés afin de traiter le cancer chez les mammifères.
Breslin Michael J.
Coleman Paul J.
Cox Christopher D.
Culberson J. Christopher
Hartman George D.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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