C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 3/10 (2006.01) A61P 25/28 (2006.01) A61P 37/00 (2006.01) C07D 221/00 (2006.01) C07D 231/00 (2006.01)
Patent
CA 2494785
The present invention provides dihydropyrazolopyridine compounds represented by the formula (I):wherein each symbol is as defined in the specification, optically active forms thereof, and pharmaceutically acceptable salts thereof and hydrates thereof. The compounds of the present invention show a selective and strong inhibitory activity on glycogen synthase kinase-3 beta (GSK- 3.beta.), and are useful as medicaments for prevention and/or treatment of diabetes, diabetic complications and neurodegenerative diseases or as immunopotentiators.
L'invention concerne des composés de dihydropyrazolopyridine de formule (I). Dans cette formule, chaque symbole est comme défini dans la description. L'invention concerne des formes optiquement actives de ces composés et des sels pharmaceutiquement acceptables desdits composés, ainsi que des hydrates de ceux-ci. Les composés de l'invention présentent une forte activité inhibitrice sélective sur la glycogène synthase kinase 3 bêta (GSK-3.beta.), et sont utiles en tant que médicaments pour la prévention et/ou pour le traitement des diabètes, de complications diabétiques et de maladies neurodégénératives, ou en tant qu'immunopotentiateurs.
Fukunaga Kenji
Hanano Tokushi
Kohara Toshiyuki
Johnston Wassenaar Llp
Mitsubishi Pharma Corporation
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