C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01) C07D 221/00 (2006.01) C07D 231/00 (2006.01)
Patent
CA 2437215
The present invention provides dihydropyrazolopyridine compounds represented by the formula (I): wherein each symbol is as defined in the specification,optically active forms thereof, and pharmaceutically acceptable salts thereof and hydrates thereof. The compounds of the present invention show a selective and strong inhibitory activity on glycogen synthase kinase-3 beta (GSK-3.beta.), and are useful as medicaments for prevention and/or treatment of diabetes, diabetic complications and neurodegenerative diseases or as immunopotentiators.
L'invention concerne des composés de dihydropyrazolopyridine représentés par la formule (I), dans laquelle chaque symbole est tel que défini dans le descriptif, leurs formes optiquement actives, ainsi que leurs sels acceptables sur le plan pharmaceutique et leurs hydrates. Ces composés présentent une action inhibitrice puissante et sélective sur la glycogène synthase kinase-3 bêta (GSK-3.beta.). On les utilise par conséquent comme médicaments pour prévenir et/ou traiter le diabète, les complications du diabète, les maladies neurodégénératives, ou comme immunostimulants.
Fujimura Masatake
Fukunaga Kenji
Hanano Tokushi
Kohara Toshiyuki
Okabe Hirotaka
Johnston Wassenaar Llp
Mitsubishi Pharma Corporation
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