Dihydropyridine-5-phosphonic acid cyclic propylene ester

Details Dihydropyridine-5-phosphonic acid cyclic propylene ester Dihydropyridine-5-phosphonic acid cyclic propylene ester

C - Chemistry, Metallurgy

07

F

167/211, 260/291

C07F 9/547 (2006.01) A61K 31/675 (2006.01) C07F 9/6571 (2006.01)

Patent

CA 1304379

ABSTRACT OF THE DISCLOSURE A compound of the formula: Image (I) wherein each of R1, R2, R3, R4, R5 and R6 which may be the same or different, is hydrogen or C1-C4 alkyl; one of X1 and X2 is nitro, fluorine, chlorine, difluoromethoxy or trifluoromethyl and the other is hydrogen, or both of X1 and X2 are chlorine; and Y is Image wherein A is C2-C6 aklylene, each of Ar1 and Ar2 which may be the same or different, is phenyl which may be substituted by chlorine, fluorine or C1-C3 alkoxy, and m is an integer of from 0 to 4, or Y is Image wherein A, Ar1 and Ar2 are as defined above when both X1 and 2 are chlorine or when X1 is hydrogen and 2 is difluoromethoxy; or a pharmaceutically acceptable salt thereof.

507085

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