C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/271
C07D 471/04 (2006.01) A61K 31/44 (2006.01) C07D 473/00 (2006.01)
Patent
CA 1302410
ABSTRACT Dihydropyridine Anti-Allergic and Anti-Inflammatory Agents Compounds of the formula:- Image (I) wherein R is phenyl or phenyl aubstituted by nitro, halo, C1-C4 alkyl, C1-C4 alkoxy, fluoro(C1-C4)alkoxy, aryl(C1-C4)alkoxy, C1-C4 alkylthio, C1-C4 alkylsulphonyl, hydroxy, trifluoromethyl or cyano; R1 and R4 are H or C1-C6 alkyl, or the two groups form a pyrrolidinyl, piperidino, morpholino, piperazinyl, N-(C1-C4 alkyl)piperazinyl or N-(C2-C4 alkanoyl)piperazinyl group; or R2 is H or C1-C4 alkyl and R1 is C3-C7 cycloalkyl, aryl, indanyl or heteroaryl, or a C1-C4 alkyl group substituted by C3-C7 cycloalkyl, C1-C4 alkoxycarbonyl, aryl or heteroaryl; R3 is OH, C1-C6 alkyloxy, aryl(C1-C4 alkoxy), or NR4R5 wherein each of R4 and R5 is independently H or C1-C6 alkyl, or the two groups form a pyrrolidinyl, piperidinol, morpholino, piperazinyl, or N-(C1-C4 alkyl)piperazinyl group; Y is an alkylene group of from 2 to 8 carbon atoms and X is 1-, 2- or 3-imidazopyridyl or 1-, 2- or 3-imidazopyrimidinyl optionally substituted by C1-C4 alkyl, C1-C4 alkoxy, halo, CF3 or CN; are antagonists of PAF and are useful in the treatment of allergic, inflammatory and hypersecretory conditions.
568064
Cooper Kelvin
Fray Michael J.
Richardson Kenneth
Cooper Kelvin
Fray Michael J.
Limited Pfizer
Richardson Kenneth
Smart & Biggar
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