Dihydropyridine anti-ischaemic and antihypertensive agents

Details Dihydropyridine anti-ischaemic and antihypertensive agents Dihydropyridine anti-ischaemic and antihypertensive agents

C - Chemistry, Metallurgy

07

D

167/231, 260/279

C07D 401/12 (2006.01) C07D 211/90 (2006.01) C07D 233/54 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1248961

Abstract "Dihydropyridine anti-ischaemic and antihypertensive agents" 1,4 Dihydropyridine derivatives of the formula:- Image (I) wherein R is aryl or heteroaryl; R1 and R2 are each independently C1-C4 alkyl or 2-methoxyethyl; Y is -(CH2)n-, -CH2CH(CH3)- or -CH2C(CH3)2-; n is 1 to 3, and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ring which may optionally be substituted by one or more C1-C4 alkyl, phenyl, benzyl, CN, -N(R3)2, (CH2)mCO2H, (CH2)mCO2(C1-C4 alkyl) or (CH2)mCON(R3)2 group wherein each R3 is independently H or C1-C4 alkyl and m is 0 or 1; and their pharmaceutically acceptable acid addition salts, and pharmaceutical preparation containing such compounds, have utility as anti-ischaemic and antihypertensive agents.

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