Dihydropyridine anti-ischaemic and antihypertensive agents,...

Details Dihydropyridine anti-ischaemic and antihypertensive agents,... Dihydropyridine anti-ischaemic and antihypertensive agents,...

C - Chemistry, Metallurgy

07

D

260/278, 260/294

C07D 211/90 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 409/04 (2006.01) C07D 413/12 (2006.01)

Patent

CA 1205480

Abstract Title: "Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions con- taining them" Dihydropyridine anti-ischaemic and antihypertensive agents of the formula:- Image (I) where Y is -(CH2)2- or -(CH2)3-; R is aryl or heteroaryl; R1 and R2 are each independently C1-4 alkyl or 2-methoxyethyl; and R3 and R4 are each independently C1-C4 alkyl or aryl- (C1-C4 alkyl); or R3 and R4 taken together with the nitrogen atom to which they are attached represent a group of the formula:- Image where R5 is C1-C4 alkyl, aryl, aryl-(C1-C4 alkyl), benz- hydryl, 2-methoxyethyl, 2-(N,N-di[C1-C4 alkyl]amino) ethyl, or cyclopropylmethyl; their pharmaceutically acceptable acid addition salts, processes for the preparation of the compounds, and pharmaceutical compositions con- taining them.

398201

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