Dihydropyridine anti-ischaemic and antihypertensive agents

Details Dihydropyridine anti-ischaemic and antihypertensive agents Dihydropyridine anti-ischaemic and antihypertensive agents

C - Chemistry, Metallurgy

07

D

167/211, 260/255

C07D 401/00 (2006.01) A61K 31/395 (2006.01) C07D 211/90 (2006.01) C07D 401/12 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 473/10 (2006.01) C07D 487/04 (2006.01)

Patent

CA 1265796

ABSTRACT "Dihydropyridine anti-ischaemic and antihypertensive agents" 1,4-Dihydropyridine derivatives of the formula:- Image --- (I) wherein R is aryl or heteroaryl; R1 and R2 are each independently C1-C4 alkyl or 2-methoxyethyl; X is a 5 or 6 membered nitrogen-containing heterocyciic ring which is substituted with one or more hydroxyl or oxo groups and which may optionally be fused to a further 5 or 6 membered nitrogen-containing heterocyclic ring, and which may optionally be further substituted in the heterocyclic ring or further fused heterocyclic ring; Y is -(CH2)n-, -CH2CH(CH3)- or -CH2C(CH3)2-; and n is 1 to 3 when X is linked to Y by a ring carbon atom, or 2 or 3 when X is linked to Y by a ring nitrogen atom; and their pharmaceutically acceptable salts, and pharmacuetical praparation containing such compounds, have utility as anti-ischaemic and antihypertensive agents.

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