A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4709 (2006.01) A61K 31/47 (2006.01) C07D 215/20 (2006.01) C07D 401/04 (2006.01)
Patent
CA 2538188
This invention relates to dihydropyridine compounds of formula: (I) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein A2, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, and m are defined herein, and compositions comprising such compounds. The invention also relates to methods of preventing or treating metabolic disorders, such as diabetes mellitus, and conditions and complications associated with diabetes mellitus, comprising administering to a subject in need thereof a compound of formula (I) or a composition comprising such a compound. The invention further relates to kits comprising a compound of formula (I).
L'invention concerne des composés de dihydropyridine de formule (I) ou un sel, un solvate, un clathrate ou un promédicament de ceux-ci acceptables sur le plan pharmaceutique, dans laquelle: A¿2?, R¿12,? R¿13?, R¿14?, R¿15?, R¿16?, R¿17?, R¿18?, R¿19?, R¿20?, R¿21?, R¿22?, et m sont tels que définis dans la description, ainsi que des compositions comprenant de tels composés. L'invention concerne également des méthodes de prévention et de traitement de troubles métaboliques, tels que le diabète sucré, et des états et des complications associés au diabète sucré, consistant à administrer à un sujet nécessitant un tel traitement un composé de formule (I) ou une composition comprenant un tel composé. L'invention concerne enfin des kits comprenant un composé de formule (I).
Borella Christopher
Chen Shoujun
Foley Kevin
Koya Keizo
Li Hao
Gowling Lafleur Henderson Llp
Synta Pharmaceuticals Corp.
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