Dihydropyridine compounds, processes for their preparation...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/90 (2006.01) C07D 401/04 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01)

Patent

CA 1300626

ABSTRACT Blood-sugar-lowering dihydropyridines of the formula Image in which R1 represents phenyl, naphthyl, thienyl, pyridyl, chromenyl or thiochromenyl, it being possible for the radicals mentioned each to carry up to 2 iden- tical or different substituents from the series comprising halogen alkyl, alkoxy and alkylthio with in each case up to 6 carbon atoms, fluoro- alkyl and fluoroalkoxy with in each case up to 3 carbon atoms and 3 fluorine atoms, nitro and cyano, R2 represents straight-chain, branched or cyclic alkyl which has up to 8 carbon atoms, can be interrupted in the alkyl chain by an oxygen or a sulphur atom and can be substituted by halogen, phenyl, cyano, hydroxyl, amino, alkylamino or dialkylamino with in each case up to 3 carbon atoms per alkyl group or by N-benzylmethylamino, R3 represents straight-chain, branched or cyclic alkyl which has up to 6 carbon atoms, can be interrupted in the alkyl chain by an oxygen atom and can be substituted by halogen, hydroxyl, amino, phenyl, morpholino, carboxy or alkoxycar- bonyl with up to 4 carbon atoms and R4 and R5 each represent hydroxyl, or R4 and R5 together represent -O-, or a physiologically acceptable salt thereof. Le A 24 766

545604

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