C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/54 (2006.01) A61K 31/47 (2006.01) A61P 5/06 (2006.01)
Patent
CA 2606521
The present invention relates to dihydropyridine derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is (1- 6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, phenyl, (1-5C)heteroaryl R2, R3 are independently (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkoxy, (2~4C)alkenyloxy, (2-4C)alkynyloxy, halogen X is SO2, CH2, C(O) or X is absent R4 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, (3- 6C)cycloalkenyl, (3-6C)cycloalkyl(1-4C)alkyl, (2-6C)heterocycloalkyl, (2- 6C)heterocycloalkyl(1~4C)alkyl, (6-1 OC)aryl, (6-10C)aryl(1-4C)alkyl, (1- 9C)heteroaryl or (1-9C)heteroaryl(1~4C)alkyl. The compounds are useful for the treatment of fertility disorders.
L'invention concerne des dérivés dihydropyridines représentés par la formule générale (I) ou un sel pharmaceutiquement acceptable de ceux-ci. Dans ladite formule (I), R1 représente (1-6C)alkyle, (2-6C)alcényle, (2-6C)alcynyle, phényle, (1-5C)hétéroaryle R2, R3 représentent séparément (1-4C)alkyle, (2-4C)alcényle, (2-4C)alcynyle, (1-4C)alcoxy, (2-4C)alcényloxy, (2-4C)alcynyloxy, halogène ; X représente SO2, CH2, C(O) ou X est absent ; R4 représente (1-6C)alkyle, (2-6C)alcényle, (2-6C)alcynyle, (3-6C)cycloalkyle, (3-6C)cycloalcényle, (3-6C)cycloalkyl(1-4C)alkyle, (2-6C)hétérocycloalkyle, (2-6C)hétérocycloalkyl(1-4C)alkyle, (6-1 OC)aryle, (6-10C)aryl(1-4C)alkyle, (1-9C)hétéroaryle ou (1-9C)hétéroaryl(1-4C)alkyle. Ces composés sont utiles pour le traitement de troubles de la fertilité.
Gerritsma Gerritdina Geziena
Van Der Veen Lars Anders
Van Straten Nicole Corine Renee
Fetherstonhaugh & Co.
N.v. Organon
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