C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/294
C07D 401/12 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07D 211/90 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2028394
ABSTRACT Dihydropyridine derivatives of the formula Image wherein R1, R2 and R3 are the same or different, and each is alkyl, cycloalkyl or alkoxyalkyl; R4 and R5 are the same or different, and each is hydrogen atom, halogen, nitro, haloge- nated alkyl, alkylsulfonyl, halogenated alkoxy, alkylsulfi- nyl, alkyl, cycloalkyl, alkoxy, cyano, alkoxycarbonyl or alkylthio (wherein both of R4 and R5 are not hydrogen atoms at the same time); X is a group represented by vinylene or azomethine; A is alkylene; B is -N(R6)2 or Image (wherein R6 and R7 are independently hydrogen atom, alkyl, cycloalkyl, aralkyl, aryl or pyridyl, Ar is aryl or pyridyl, and n is an integer of 0 to 2), acid addition salts thereof and pharmaceutical compositions containing same are dis- closed. They exhibit potent and long-lasting antihyperten- sive action and can be used as a medicine for prevention and treatment of hypertension and so on.
Ashimori Atsuyuki
Fukaya Chikara
Ohtaki Yutaka
Yokoyama Kazumasa
Ashimori Atsuyuki
Fetherstonhaugh & Co.
Fukaya Chikara
Ohtaki Yutaka
The Green Cross Corporation
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