C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/278, 260/294
C07D 211/90 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01)
Patent
CA 1337295
Compounds are described of the formula : Image (I) and physiologically acceptable salts thereof, in which R1 represents hydrogen or C1-4 alkyl, R2 represents hydrogen, C1-6 alkyl or phenyl(C1-3)alkyl in which the phenyl ring may be substituted by a nitro, C1-3 alkyl 9 C1-3 alkoxy or hydroxyl group or a halogen atom, or R1 and R2 may together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, hexamethylenimino, morpholino, thiamorpholino, thiamorpholino 5-oxide, thiamorpholino 5,5-dioxide, piperazino, N-methylpiperazino or N-phenylpiperazino ring; Alk represents a methylene or ethylene chain. R3 and R4 independently represent a C1-6 straight or branched chain alkyl or alkoxyalkyl group; R5 represents C1-4 alkyl; R6 represents a C1-13 alkyl group or a C5-8 cycloalkyl group which may be substituted by C1-3 alkyl; and R7 represents a halogen or hydrogen atom or a C1-3 alkyl group. The compounds represented by formula (I) reduce intracellular calcium ion concentration by limiting transmembranal calcium ion concerntration and thus may be useful for the treatment of cardiovascular disorders such as hypertension.
516391
Borthwick Alan David
Gaviraghi Giovanni
Micheli Dino
Pieraccioli Daniele
Semeraro Claudio
Glaxo S.p.a.
Riches Mckenzie & Herbert Llp
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